Is there a specific triglyceride level at which you discourage patients with metabolic syndrome from starting GLP-1R agonist therapy due to the risk of pancreatitis?

Overwhelming data show that acute pancreatitis is not directly due to GLP-1 use but rather the indirect effect of rapid weight loss leading to cholelithiasis and subsequent acute biliary pancreatitis in GLP-1 users. Hypertriglyceridemic pancreatitis is rare even among those with elevated TG levels (...

The usual recommended cut-off is TG > 500 mg/dl. In practical terms, this limit can be affected by lifestyle (nutritional and exercise) approaches and glycemic control, if indicated. Also, it is worth keeping in mind that concurrent gallbladder disease and cholelithiasis, more common in people with ...