Is there an SIB boost regimen for a dominant prostate lesion for 60 Gy/20 fx to the whole prostate?

Topics: Radiation Oncology • Genitourinary Cancers

Answer from: Radiation Oncologist at Academic Institution

There are no phase III data providing guidance on the "isotoxic" boost dose for a 20-fraction, hypofractionated prostate treatment similar to the experimental arm in FLAME (Kerkmeijer et al., PMID 33471548), but there are two prospective studies of which I am aware, DELINEATE and ARO2020-01, which d...

Comments

Radiation Oncologist at Brooke Army Medical Center
Given your answer, it sounds like EBRT urethral co...

Radiation Oncologist at Alabama Cancer Care
The protocol for the ongoing SUPR-SABR trial at MU...

Radiation Oncologist at National Institutes of Health Clinical Center
Hi Dr. @Smith - I think it will become more of an ...

Answer from: Radiation Oncologist at Community Practice

Dr. @Patel has a good summary of the data. Outside of that, the NRG GU-010 trial allows for microboost and offers guidance for different dose/fractionation regimens based on BED conversions assuming an alpha/beta of 3. If using these non-validated regimens, I would encourage anyone to appropria...

Answer from: Radiation Oncologist at Academic Institution

40 Gy/20 fractions is highly likely to eradicate subclinical carcinoma so 60/40 would be a good choice.

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