Is there evidence for dose escalation of large bony metastases secondary to hepatocellular carcinoma?

Interesting question. The thing with HCC bone mets is that if you use only a nuclear bone scan to contour GTV you miss tumor, according to a paper from Korea (1), because HHC bone mets tend to have large soft tissue components.

Further, a Japan report(2) from 1998, looked at successful pain relief o...