Outside of a clinical trial, what is your preferred first-line therapy for a fit patient with de novo metastatic spindle cell sarcoma?

Hard to answer definitively without knowing the location of primary and better clinical and/or pathology clarification. Assuming a better definition of path is not possible, I would favor Doxorubicin (75 mg/m2) plus Ifosfamide (10 g/m2 divided into 4 or 5 daily doses). Additional information may wel...