Blood Adv 2020 Jan 28
American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.
Related Questions
What is your approach to optimizing pre-operative hemoglobin in patients with sickle cell disease?
This is always a question that has to be hyper-individualized. The research, and therefore the associated professional guidance, is thin. The American Society of Hematology (ASH) 2020 Guidelines for Sickle Cell Disease: Transfusion Support and the NHLBI Expert Panel Report (2014) are the only profes...
In a patient hospitalized for several days with a refractory pain crisis would you ever consider transfusion, either simple or possibly exchange in an attempt to get the patient over the crisis?
While chronic transfusion therapy has been shown to prevent acute vaso-occlusive pain episodes (see studies that used chronic transfusion to prevent primary and secondary stroke), there are limited data to determine if they are effective for treatment of acute pain caused by vaso-occlusion. There ha...
What is the transfusion management of a sickle cell patient during pregnancy?
Prophylaxis: There is an ongoing trial in transfusion management in pregnancy, comparing prophylactic red cell exchange to a target HbS or SC < 30% compared to transfusion only when clinically indicated. Interestingly, it does not specify a Hct target. Until that trial is done, I would follow the AS...