What is your approach to optimizing pre-operative hemoglobin in patients with sickle cell disease?
How do you decide between simple transfusion and red cell exchange?
While the 2020 ASH Guidelines provide some conditional guidance on transfusion support, evidence appears to be limited, and several research questions on the topic remain unanswered.
2 Answers
Mednet MemberInvited Expert
Hospital Medicine · Johns Hopkins Hospital
Answered on
This is always a question that has to be hyper-individualized. The research, and therefore the associated professional guidance, is thin. The American Society of Hematology (ASH) 2020 Guidelines for Sickle Cell Disease: Transfusion Support and the NHLBI Expert Panel Report (2014) are the only profes...
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Mednet MemberInvited Expert
Hospital Medicine · University of Iowa Hospitals and Clinics
Answered on
Unfortunately, I am not aware of a more comprehensive document than the ASH guidelines. These are what I use to define my default management strategy, often in coordination with our dedicated hematology consult subspecialist service.
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