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N Engl J Med 2018 Mar 29
Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.   

Related Questions

What is the preferred number of cycles of CAPOX for rectal cancer receiving total neoadjuvant chemotherapy?
New comment by Medical Oncologist at Oregon Health & Science University ( June 16, 2021)
I do not give any additional therapy in this situation, as there is no evidence to support the benefit of such treatment. 
In a patient with low risk T3N1 stage III colon cancer unable to tolerate CAPOX due to profound GI toxicity, would you switch to FOLFOX and extend to 6 months of adjuvant therapy?
New answer by Medical Oncologist at Memorial Sloan Kettering Cancer Center (November 29, 2021)
While I certainly agree the problem lies with the capecitabine far more than the oxaliplatin, I would approach this patient a little differently. Consider that we are told tha...
What adjuvant therapy would you offer for rectosigmoid junction adenocarcinoma after initial LAR?
Final pathology showed pT3N0, 0/27 nodes, negative margins +perforation, +PNI, pMMR.
New comment by Radiation Oncologist at UT Southwestern Medical Center ( April 21, 2022)
Per ASTRO guidelines for pre-op RT, the following scenarios would be appropriate to consider omission of RT in the PRE-op setting: T3a/b, N0, >10 cm from the anal verge, no...
Would you continue adjuvant FOLFOX for a patient with stage III colon cancer and triple-vessel coronary artery disease who developed NSTEMI after the first cycle?
If so, would you adjust 5-FU dosing?
New comment by Medical Oncologist at UAB, Birmingham ( April 28, 2022)
Great questions. Capecitabine has been shown to have similar risk of cardio-toxicity to 5-FU. It is pharmacokinetically similar to continuous infusion of 5-FU. Also, the ...
What adjuvant chemotherapy would you recommend in a elderly patient with resected stage III colon cancer with MMR deficiency with MLH1 promoter hypermethlation?
New answer by Medical Oncologist at Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty (May 29, 2022)
Approximately 60% of the stage III dMMR colon cancer patients are cured after surgical resection and at most, only 10–15% benefit from oxaliplatin-based adjuvant treatme...
Which group of Stage III MSI-H colon cancer patients can be excluded from receiving adjuvant chemotherapy? 
New answer by Medical Oncologist at Mary Lanning Healthcare Morrison Cancer Center/University of Nebraska Medical Center Adjunct Faculty (January 10, 2023)
10% to 15% of patients with early-stage, and 4% of patients with metastatic colorectal cancer (CRC) test positive for dMMR. In stage II-III colon cancers, MSI-H/dMMR status is...
Would you give a fit <40 year old with T3N1b low risk Stage IIIB colon adenocarcinoma 6 months of adjuvant chemo or feel comfortable limiting to 3 months of CAPOX?
Does the patient's young age affect your decision when applying data from the IDEA collaboration?
New answer by Medical Oncologist at Rutgers Cancer Institute of New Jersey (April 9, 2023)
For T3N1 disease, 3 months of therapy with oxaliplatin and fluoro-pyrimidine is non-inferior to 6 months. Statistically equivalent with an upper limit of 95% CI <1.12. Furt...
Would you offer additional systemic treatment to a stage II or III resected colon cancer that received 3 months of adjuvant capecitabine/oxaliplatin and now is presenting with a solitary lung metastasis?
And if so, would you offer it pre or post-metastasectomy? Would time to recurrence or ctDNA play a role?
New answer by Medical Oncologist at Oncology Consultants (January 4, 2024)
I agree with Dr. Sahin, however, if lung nodule is new and developed more than 12 months from adjuvant therapy, I would suggest ctDNA, followed by surgical resection, then can...
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