Int J Radiat Oncol Biol Phys 2000 May 1
Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05.
ABSTRACT
PURPOSE
To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases.
METHODS AND MATERIALS
Adults with cerebral or cerebellar solitary non-brainstem tumors
RESULTS
Between 1990-1994, 156 analyzable patients were entered, 36% of whom had recurrent primary brain tumors (median prior dose 60 Gy) and 64% recurrent brain metastases (median prior dose 30 Gy). The maximum tolerated doses were 24 Gy, 18 Gy, and 15 Gy for tumors
CONCLUSIONS
The maximum tolerated doses of single fraction radiosurgery were defined for this population of patients as 24 Gy, 18 Gy, and 15 Gy for tumors
Related Questions
New comment by Radiation Oncologist at Mallory Radiotherapy, PLLC ( March 4, 2020)
How would you recommend treating a small (3-4 mm) melanoma met in the brainstem when using LINAC-based SRS (VMAT planning)? What dose fractionation would you use and PTV margi...
What fields would you use for adjuvant RT? SBRT vs. whole brain?
New answer by Radiation Oncologist at St Jude Children's Research Hospital (December 14, 2017)
While an uncommon occurrence in pediatric sarcomas, as much as 2-3% of pediatric RMS and EWS cases can metastasize to the CNS. The optimal management strategy has not been eva...
How does the presence of prior WBRT alter your treatment plan?
New comment by Radiation Oncologist at Beaumont Hospital ( February 12, 2021)
Our experience may be a bit different. We have treated about 20 patients with F SRS following resection and in about 1/2 of the cases, there has been post op MRI evidence of r...
Does the previous dose of SRS or the fact the patient had prior surgery matter when planning WBRT?
New answer by Radiation Oncologist at Ohio State University James Cancer Center (December 13, 2022)
If a patient remains a candidate, I prefer to offer hippocampal sparing WBRT whenever possible, respecting the hippocampal constraints outlined in RTOG 0933 (Hippocampus D100%...