Should a glioma patient on phenytoin be completely tapered off prior to starting radiation?

Toxic epidermal necrsosis during cranial radiation has been reported, although very rare. In pateints with no such history, I have not seen any similar complication. However, it would be better to taper off the drug if the patient has a history of the skin condition.

When a phenytoin induced skin rash develops during radiotherapy, the rash usually disapppears after discontinuing the drug and treating with dexamethasone and diphenhidramine. If the skin condition is more genralized or worsens, on...