Should we be aiming for normalization of both late-night salivary cortisol and 24hr urinary free cortisol levels when monitoring response to Cushing's disease treatment?

I usually follow UFC, but there is some data that in patients with Cushing disease treated with pasireotide there was a greater improvements in systolic/diastolic blood pressure and weight in patients with both normal late night salivary cortisol and UFC compared with only normal UFC (see: Newell-Pr...

Ideally, yes, both should be normal. 24 hour UFC may increase but still be within the normal range so normal salivary cortisol provides additional reassurance.