Should we repeat a dose-escalation trial for stage III NSCLC in the era of modern radiotherapy techniques and dose constraints?

Yes to a study with modern techniques. The outcome was so odd that high dose was killing patients at a higher rate than with standard dose, despite many phase II and retrospective studies showing good outcomes. The subset analyses showing that IMRT was associated with better outcomes as well as more recent publications discussing cardiac/substructure dose gives me pause to throw the baby out with the 70 Gy bathwater. It appears that when you consider the dose to the heart, the treatment arm effe...