Should whole brain radiation therapy and orbital radiation therapy be administered in situations of ocular B-cell lymphoma recurrence 2 years after primary CNS lymphoma treated with intrathecal methotrexate and no prior cranial irradiation?

There are multiple small series showing good a salvage rate with radiation therapy with acceptable morbidity for patients who have failed prior MTX. The outcome is dictated by age and extent of disease and accordingly one can plan for a palliative or definitive dose.