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What adjunctive therapies to you recommend for symptom control in acute opioid withdrawal beyond full/partial opioid agonists?

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Which adjunctive non-opioid medications have you prescribed to treat opioid withdrawal symptoms?

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2 Answers
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Hospital Medicine · Oregon Health Sciences University (OHSU)
Answered on

Here are some general recommendations below. I recommend asking the patient what symptoms are most bothersome or what they anticipate to be the most bothersome when prescribing adjuncts. I routinely recommend APAP/ibuprofen, and then usually prescribe something for anxiety and nausea. Tizanidine can...

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General Internal Medicine · UPMC
Answered on

Full agonists like oxycodone/hydromorphone, non-opioids like clonidine, guanfacine, tizanidine, and anti-emetics.

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