What adjunctive therapies to you recommend for symptom control in acute opioid withdrawal beyond full/partial opioid agonists?

Here are some general recommendations below. I recommend asking the patient what symptoms are most bothersome or what they anticipate to be the most bothersome when prescribing adjuncts. I routinely recommend APAP/ibuprofen, and then usually prescribe something for anxiety and nausea. Tizanidine can...

Full agonists like oxycodone/hydromorphone, non-opioids like clonidine, guanfacine, tizanidine, and anti-emetics.