When do you use extended-release buprenorphine instead of daily formulations?

Extended-release buprenorphine (e.g., Sublocade, Brixadi) can be a good option for patients who have trouble staying stable on daily sublingual doses, especially those with adherence challenges, ongoing exposure to high-risk opioids such as fentanyl, or concerns about safety and diversion. Weimer et...

A multisite pragmatic open-label trial (n=140) of weekly XR buprenorphine vs. SL bup (bup with or without nx) during pregnancy was recently published and showed that there was a significantly higher proportion of illicit opioid negative urine tests during pregnancy (XR: 82.5% vs. SL: 72.6%; p=0.009)...