What adjuvant chemotherapy is preferred in primary ovarian mucinous adenocarcinoma of intestinal type?

Mucinous ovarian cancers are rare (3-4%) and are distinct from high grade serous ovarian cancers. Many of our trials for adjuvant chemotherapy in ovarian cancer only included small percentages of patients with mucinous histology (typically less than 5% entered in trials). While serous tumors tend to have BRCA and P53 alterations, these are less common in mucinous tumors, which tend to have KRAS alterations 50-70%).

We do recommend assessing for GI primary including upper and lower endoscopy and CEA serum marker in cases with mucinous histology.

NCCN guidelines list both standard platinum + taxane based chemotherapy in the adjuvant setting as well as 5-FU + leucovorin + oxaliplatin based regimens.

The GOG looked at chemotherapy regimens for th...

Agreed.