What adjuvant systemic therapy do you recommend for a pre-menopausal patient with a localized recurrence of ER+PR+HER2- invasive ductal carcinoma while on adjuvant ovarian suppression with an aromatase inhibitor?
Answer from: Medical Oncologist at Community Practice
This is a difficult clinical scenario. First, I would determine whether she was compliant with her medication. With the assumption that she was compliant, I would say that there is a paucity of data in this setting. The final analysis of the CALOR trial demonstrated that, after a median of 9 years, ...
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Answer from: Medical Oncologist at Academic Institution
I agree with the proposed plan to consider curative intent chemotherapy for local recurrence. However, I would consider changing her hormone therapy to a drug with a completely different mechanism of action such as tamoxifen as she may have an ESR mutation or some other biologic mechanism conferring...
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Medical Oncologist at Columbia University Medical Center
I agree with Heather and Kevin. I would also try t...
I agree with Heather and Kevin. I would also try t...