What adjuvant therapy do you recommend for stage III colon cancer patients unable to tolerate 5FU regardless of modality/dose reduction?

There is no high-quality evidence to support adjuvant chemotherapy for colorectal cancer with a non-fluoropyrimidine regimen. For patients at high risk for colon cancer recurrence, effort should be taken to find a dose or mode of fluoropyrimidine administration that is feasible. For instance, bolus administration of 5-FU can be safely done in many patients who have coronary vasospasm with infusional 5-FU or capecitabine. For patients with DPD deficiency, CPIC guidelines recommend safe chemothera...