What adjuvant therapy would you recommend for a T3N0, grade 3, undifferentiated sarcoma of the mandible with positive margins that is not amenable to re-resection?

Topics: Radiation Oncology • Sarcoma • Medical Oncology

Would you offer adjuvant RT or chemotherapy? If so, what chemotherapy would you prefer?

Answer from: Radiation Oncologist at Academic Institution

From a radiation standpoint, I would offer adjuvant radiation therapy. Given positive margin, would image to make sure no gross disease. If microscopic positive margin, I would go to 66-70 Gy.

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Radiation Oncologist at University of Florida
Postop RT.

Answer from: Radiation Oncologist at Academic Institution

Not much in the mandible is unresectable. I would get the patient a second surgical opinion with an experienced ENT surgical oncologist. Regardless of use of RT, R0 margins are necessary for optimal local control in STS so would want to evaluate for any possibility of re-resection. (A nuance to this...

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