What adjuvant treatment approach would you choose for a premenopausal woman with lymph node positive poorly differentiated metaplastic breast cancer that is ER low+, PR+, HER2 negative?

Topics: Breast Cancer • Medical Oncology • HR+ • Breast Cancer, Non-metastatic

Is there a role for KEYNOTE-522 since ER + metaplastic breast cancer have similar behavior to triple negative metaplastic breast cancer?

Answer from: Medical Oncologist at Academic Institution

Given the tumor is ER low+ (and I'm going to assume not strongly PR+ in this case since that would be highly unusual in the setting of ER low positivity only...but please comment back if I'm wrong!), yes, I would consider this biologically triple-negative disease (and very high risk given metaplasti...

Comments

Medical Oncologist at Geisinger Medical Center
Thanks for commenting. What if the tumor on biopsy...

Medical Oncologist at Harvard Medical School
Oops, sorry, I missed that you are treating this i...

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