What adverse features would prompt you to give post-TORS radiation therapy to completely resected early stage (T0-2) p16+ tonsillar cancer?

I would base my recommendation on the standard and conventional indications for PORT, which in this case of an early-stage primary tumor with negative margins, would comprise the presence of PNI, LVI, close (<3-5 mm) margins, single node >3 cm, or multiple positive nodes. I assume there is no extrac...

Indications:

Dr. @Dr. First Last gave a very nice summary of the indications for treatment as well as the nuances, and that even within the non-ENE nodal disease (as most of the post TORs recommendations are based on neck per ECOG and our own experience), there is a gradation of risk. On the other h...

This question is only controversial because the accepted standard treatments for low-intermediate risk p16+ patients are either a hammer or do nothing at all.

The risk of relapse for low-intermediate risk patients is still around 12%, of which a quarter will fail in a fashion not amenable to salvage ...