What adverse pathological features would be an indication for WBI (whole breast irradiation) after a patient receives IORT for early breast cancer?

Outside of the core TARGIT-A protocol, there are no other official protocol-defined pathological features warranting adjuvant EBRT. The protocol however allowed for centers to add other path risk factors justifying EBRT ie extensive LVSI +/- G3 +/- SMS .2-1cm +/- +SnLN.

Mitigating risk of recurrence ...