What AEDs prevent spikes and sharp waves?

Good question, but the way it is phrased makes it difficult to answer:

• Generally, all ASMs can suppress seizure activity and interictal discharges to some degree.
• There is a huge difference among the subtypes of epilepsy, for example in IGE and LGS, there may be a correlation between the interictal burden and seizure control but in focal epilepsies that is not the case.
• Suppressing interictal discharge is not our goal.
• There is no known significant difference among ASMs in terms of specifically suppressing interictal discharges, as long it is the correct ASM for the type of epilepsy.

Ushtar Amin, MD
@Dr. First Last, MD

Both Keppra and Depakote are capable of suppressing spike and wave.

I agree with Dr. @Dr. First Last.