What agents can you use for treatment induction besides rituximab in cryoglobulinemic vasculitis (without hepatitis)?

The choice of induction/immunosuppression depends on the severity and is very similar to small vessel vasculitis like ANCA-associated vasculitis. So in addition to rituximab, cyclophosphamide is a very good induction agent for severe forms. This is one condition where plasma exchange is highly recommended.

For milder forms, even methotrexate alone can be used.

Mukhtyar et al., PMID 18413444