What alternate neo-adjuvant backbone chemotherapy would you recommend in a patient with ER+ HER2+ clinical stage II breast CA with severe pan-colitis following a cycle of TCHP with docetaxel?

I would switch to weekly paclitaxel and carboplatin with trastuzumab only, but might retry pertuzumab if the patient gets through 6 weeks without recurrent diarrhea. This is actually my preferred version of TCHP (including the pertuzumab), which I find to be better tolerated than the every-3-week do...

I've seen docetaxel induced severe colitis (and this has been described). The typical characteristics of taxane induced colitis was described by Chen et al., PMID 31892799, and may be helpful to sort this out. However, the likely culprit I think is still pertuzumab. The CR rate of TCHP is lessened w...

NCCN-based options include Doxorubicin/Cyclophosphamide followed by paclitaxel with trastuzumab for 1 year commencing with the first dose of paclitaxel as a preferred HER2-targeting adjuvant regimen. The Docetaxel/Carboplatin/Trastuzumab regimen is also a preferred
regimen, especially for those with ...