What approach, or dosing interval, do you find is most effective reducing side effects of Hedgehog Inhibitors (i.e., vismodegib) for patients with numerous BCC?

I have scarcely used hedgehog inhibitors as a preferred treatment in BCC. I rely more on Immunotherapy or clinical trials or even prefer local RT for a non-IO responsive BCC. Having said that, I usually begin at full dose and go down to alternate day dosing if patients have terrible side effects. I ...

As a former speaker for one of these medications, I rarely use sonic hedgehog inhibitors nowadays. That said, I recently saw a Gorlin’s patient who successfully was treated for seven years with good effect and remarkable tolerance. That ultimately is the problem with the class of medicines: that eve...