What are best practices in management of severe acute infusion reaction from infliximab?
Patient became acutely flushed, developed severe and prolonged hypotension with brief loss of consciousness, dizziness, nausea, dry heaves and headache. She had no chest pain, wheezing or lip/tongue swelling.
1 Answer
Mednet MemberInvited Expert
Rheumatology · Dartmouth-Hitchcock Medical Center
Answered on
Severe infusion reactions to infliximab are not typically IgE-mediated. The presumption is that it is ‘anaphylactoid’ due to IgG antibodies directed against the mouse chimeric proteins in the molecule. Stopping the infusion is essential (at least temporarily) and administering antihistamines such as...
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