What are the benefits and potential risks of using bisphosphonates for pseudoxanthoma elasticum?

There are not a lot of data regarding the use of bisphosphonates in pseudoxanthoma elasticum (PXE). The major pathogenic event in PXE is ectopic mineralization of elastic tissue in middle-size arteries, Bruch’s membrane of the choroid (predisposing to choroidal neovascularization and retinal bleeds ...

Tough condition to treat, I typically would use a fractional erbium YAG or CO2 laser, and would do a test spot first and follow-up, but I found this condition very hard to treat with any modality.