What are your top takeaways in Neuro Oncology from ASCO 2025?

Answer from: Radiation Oncologist at Academic Institution

Aizer et al., JCO 2025 - A multi-instituitional Brigham Dana-Farber-led trial randomized 196 patients with 5-20 brain metastases to stereotactic radiosurgery (SRS) or hippocampal avoidance whole brain radiotherapy (HA-WBRT). Patients treated on the SRS arm had significantly less symptom burden, wi...

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Radiation Oncologist at Southeast Radiation Oncology Group, P.A.
Thank you, @Paul D. Brown! Do you happen to know i...

Radiation Oncologist at Southeast Radiation Oncology Group, P.A.
Actually, I see that the median number was 14, but...

Radiation Oncologist at Mayo Clinic
That is correct; the median number was 14. I could...

Answer from: Radiation Oncologist at Academic Institution

The study from Boston on radiosurgery versus whole brain for up to 20 brain mets is quite a discussion in my department. My understanding is that radiosurgery for multiple brain mets up to 20 appears to have favorable neurocognitive preservation rather than whole brain.

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What are your top takeaways in Neuro Oncology from ASCO 2025?

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