What biomarkers or patient characteristics do you feel best predict response to B cell depleting therapies in a patient with Sjogren's?  

At present, it may depend on the Sjogren's phenotype being treated with B-cell depleting therapies. If it is vasculitis with or without cryo, cryoglobulins, rheumatoid factor, and complements are helpful, along with inflammatory markers (ESR/CRP). I also note the level of total IgG, if elevated, may...

At this point, I do not think there is a consensus about clinically available biomarkers that reliably predict response rate to B-cell-depleting therapies in SjD. There are some research studies pointing to changes in flow cytometry, immunohistopathology, and cytokine production, but these research ...