What chemotherapy backbone will you use with pembrolizumab in the neoadjuvant setting for triple negative breast cancer?

I don't have an answer to this, but just opinions. There are several decisions that we will need to make regarding how to best use immunotherapy, unfortunately without much data to guide us:

1) What chemo backbone to use?

2) Do we really need to continue pembro adjuvantly? If so, in whom? Everyone? On...

I would caution the comparison with data from GeparNuevo due to the small number of patients and different drugs and schedules. GeparNuevo used neoadjuvant nab-paclitaxel and q2-week EC and KEYNOTE-522 used paclitaxel/carbo and q3-week AC. We know that based on GeparSepto (large phase 3 study), neoa...