What chemotherapy backbone will you use with pembrolizumab in the neoadjuvant setting for triple negative breast cancer?

Topics: Breast Cancer • Medical Oncology • Triple negative • Breast Cancer, Non-metastatic

Will you incorporate carboplatin into the backbone as it was done in the KEYNOTE trial?

Answer from: Medical Oncologist at Academic Institution

I don't have an answer to this, but just opinions. There are several decisions that we will need to make regarding how to best use immunotherapy, unfortunately without much data to guide us:1) What chemo backbone to use?2) Do we really need to continue pembro adjuvantly? If so, in whom? Everyone? On...

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Medical Oncologist at Mayo Clinic Rochester
Thanks for raising all the important questions!!&n...

Answer from: Medical Oncologist at Community Practice

I would caution the comparison with data from GeparNuevo due to the small number of patients and different drugs and schedules. GeparNuevo used neoadjuvant nab-paclitaxel and q2-week EC and KEYNOTE-522 used paclitaxel/carbo and q3-week AC. We know that based on GeparSepto (large phase 3 study), neoa...

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