What considerations do you take regarding using valproic acid in men who are hoping to conceive with a partner?

This recommendation was based on an analysis of one retrospective study, with data being re-analyzed, in addition to case reports and animal studies. It seems to me that it's too soon to be making rash decisions about treatment, but informing patients of the possibility and uncertainty seems reasona...

It is a balance between patient stability and potential concerns with kids. However, I do not use VPA frequently due to multiple side effects.

I also find Depakote to be problematic because of problems with tolerance, as well as difficulty getting patients to follow through with lab work. I would lean towards switching to a different medication but would leave the ultimate decision to the patient.