What criteria do you use for induction chemotherapy in advanced head and neck cancers?

We were advocates of IC for patients felt to be at higher risk for DM in oropharynx cancer. We believed these were patients with N2b-N3 disease. However, the recent PARADIGM and DeCIDE trials were negative for a survival advantage for IC, so personally my enthusiasm for IC for advanced oropharynx ca...

Almost never. Maybe for T4b or N3 non-oropharynx pharyngeal cancers. We use it most routinely for metastatic nasopharyngeal cancer in an attempt to gain control over distant disease prior to local-regional consolidation. We use it for marginally resectable or unresectable sinonasal neuroendocrine tu...