What data exist regarding treatment for facial erythema from dupilumab in children <5 years of age?

In AD patients >6 years, the incidence of facial erythema for dupilumab was 1% vs placebo 0.7% (Paller et al., PMID 41163262). The placebo-controlled LIBERTY AD PRESCHOOL trial (Paller et al., PMID 36116481) and the subsequent open-label trial up to 2 years (Paller et al., PMID 41926052) for 6-month...

I am unaware of any data.

However, pre-pubertal children should not be producing enough facial oil to support the growth of Malassezia yeast, so there is no indication for use of anti-yeast medications in this age group as there is in adults.

Patch testing for all potentially allergenic components o...