What do you do when a patient experiences multiple rounds of antidepressant-related tachyphylaxis?

Our clinic is having remarkable success with TMS for those patients.

Restoration of hope remains relational in most difficult-to-treat cases.

1. TMS is the best evidence-based for a very safe profile, few side effects, and sustained recovery.
2. Supportive psychotherapy can provide essential sustaining hope in difficult-to-treat depressive patients.
3. The 6 pillars of the L...

I have found that with tachyphylaxis patients often respond to rotating medications to a similar in-class medication (i.e., a different SSRI or SNRI) with a slight deviation in the chemical structure often (but not always) helps for a while. After a few years, I often revert to the original medicati...