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What do you quote the risk of radiation necrosis with repeat SRS/SRT to the same lesion?

In what situations would you or would you not offer repeat SRS/SRT to the same lesion?
2 Answers
Mednet MemberInvited Expert
Neurosurgery · Yale
Answered on

The answer to this question is not a matter of debate.

Sneed et al., PMID 25978710

"The most important risk factors for ARE included prior SRS to the same lesion (with 20% 1-year risk of symptomatic ARE vs 3%, 4%, and 8% for no prior treatment, prior whole brain radiotherapy [WBRT], or concurrent WBR...

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Mednet Member
Radiation Oncology · Lynn Cancer Institute - Baptist Health City, Baptist Health South Florida
Answered on · Updated on

Regarding the first question, the risk of radionecrosis/adverse radiation events (both radiographic/G1 as well as symptomatic/G2 and above) is quite multifactorial, depending on time elapsed from the initial course of SRS, the volume treated of initial disease and the volume planned to be re-treated...

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