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What do you use for treatment induction in pure class V lupus nephritis with nephrotic-range proteinuria when MMF is contraindicated?

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Mednet Member
Mednet Member
Rheumatology · NYU Langone Health

I'll begin my response by commenting that other than an allergic reaction, which is very rare or pregnancy, there is really no absolute contraindication to MMF. On the other hand, there are patients who cannot tolerate MMF most often due to G.I. side effects in which case mycophenolic acid is an opt...

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Mednet Member
Mednet Member
Nephrology · Feinberg School of Medicine

If pure class V without any proliferation, I would use rituximab or a CNI. Both of those agents are effective in non lupus membranous. Cyclophosphamide is also an option.

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What do you use for treatment induction in pure class V lupus nephritis with nephrotic-range proteinuria when MMF is contraindicated? | Mednet