What dose are you routinely using for adjuvant RT for intermediate risk p16+ SCC of the OPX s/p TORS?

It's still just a phase II trial. Even the authors state in the introduction that their primary objectives were to demonstrate the feasibility of a prospective multi-institutional study of TOS for HPV+ OPC followed by risk-adjusted adjuvant therapy and that a planned phase III trial is in developmen...

I think this question exemplifies the problem with dose de-escalation, as the question asks what dose, but doesn't specify to what. ECOG 3311 gave 50 Gy to a larger volume and then randomized a 10 gy yes/no boost. So both 50 and 60 Gy are the correct standards of care.

Most 'intermediate risk' TOR pa...

60 Gy/30 fractions.

60 Gy high-risk post-op site/54 Gy low-risk neck in 30 Fx with SIB technique, until we have quality phase III data as mentioned above. For some appropriately selected patients, we can get away with unilateral neck treatment. I would love to have phase III justification for reducing my doses for this...