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What dose constraints do you use for the left anterior descending artery (LAD) for breast radiation?

Is there data to support those constraints?
2 Answers
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Radiation Oncology · UPMC Shadyside
Answered on

We published in the Red Journal in 2022 a single-institution analysis of LAD/heart dosimetry and association with cardiac events in 375 patients with a history of left-sided breast or chest wall irradiation: Zureick et al., PMID 35483540

LAD Dmean EQD2 of 2.8 Gy and LAD Dmax EQD2 of 6.7 Gy were found...

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Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on

There are quite a few numbers in literature and more will come.

LAD dose also tends to correlate with mean heart dose and LAD dose may be more significant than mean heart dose to long-term risk of CAD in breast cancer patients.

We contour LAD and avoid any direct beam going through the vessel and th...

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