What dose do you prescribe when treating the prostate in patients with low metastatic burden and what are your dose constraints?
I follow the STAMPEDE regimen - either 55 Gy in 20 daily fractions or 36 Gy in 6 weekly fractions. One of the imperatives of the STAMPEDE investigators was to not subject men with low volume metastatic prostate cancer to toxicity - and they found these doses of did not, while still significantly imp...
We've been debating this issue at our institution, too. STAMPEDE also used a 6 Gy x6 delivered one fraction per week regimen.
As these are patients likely to live a long time, even if not cured, then the goal in treating the prostate should be to achieve durable local control, while at the same time...
Converting to U.S.-style 5 fraction prostate SBRT, would anyone give 7.25 Gy per fraction x 5 fractions for 36.25 Gy, or use a different dose? Treating once weekly, twice weekly, or thrice weekly?