What dose-fractionation do you utilize when treating at-risk and elective lymph node levels in patients with HPV-positive oropharyngeal squamous cell carcinoma?

For HPV+ OPC getting definitive concurrent chemoRT, we have been treating the elective nodal levels to 30 Gy at 2 Gy per fraction in the past 5 years (Tsai et al., PMID 35050342). For those treated with definitive RT alone (or with cetuximab) or in the adjuvant setting, we did not reduce the dose in...

Altered fractionation 50.4 at 1.2 bid or 56 at 1.6 per fx 6 fx per week