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What dose/fractionation regimen do you use for the moderately accelerated, hypofractionated treatment of localized prostate cancer?

There are a wide range of seemingly safe/effective regimens in the published literature, with an associated array of BED/EQDs and little more to guide one in choosing the optimal scheme.
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What dose/fractionation regimen do you use for the hypofractionated treatment of localized prostate cancer?

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1 Answer
Mednet Member
Mednet Member
Radiation Oncology · Duke University School of Medicine
Answered on

I use 70 Gy in 28 fractions. Rationale in brief below-

  1. Tested and proven to be non-inferior in RTOG 0415
  2. Less valid but important; we have been using this regimen at the Durham VA for nearly a decade.
It is hard to be dogmatic; several regimens have been described in the literature but only two have be...

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