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What dose fractionation schedule do you use to treat head and neck cancer in a patient with Fanconi's Anemia?

Patient's with Fanconi's anemia can have severe/fatal toxicity with chemotherapy and radiation but unfortunately can also present with aggressive head and neck cancers at a young age. How would you approach a locally advanced H&N squamous cell carcinoma in a patient with Fanconi's anemia?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · University of Florida
Answered on

If p16 positive oropharynx, 1.2 Gy bid to 64.8 Gy. Otherwise 74.4. Probably no chemo.

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