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What dose is required to gross disease in the definitive treatment of vulvar cancer?

For definitive vulvar ca, is 5940 cGy the minimum acceptable dose for gross disease? 5760cGy? Or should the dose be escalated beyond 60Gy?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of Texas MD Anderson Cancer Center
Answered on

As with all gynecologic carcinomas, the optimal dose is at least to some extent dependent on the volume of disease. However, our experience suggests that a minimum of 60 Gy should always be given for gross diasease, even when concurrent chemotherapy is being given. That said, for gross disease that is more than 1.5-2 cm in diameter, we try to give a higher dose of at least 64-66 Gy and sometimes even more if the anatomy permits. The dose is sometimes tempered by the proximity of critical structu...

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Mednet Member
Radiation Oncology · Quint Cities Radiation Oncology
Answered on

Another good resource for contouring and treatment recommendations for vulvar carcinoma which echo @Dr. First Last's post:

http://www.redjournal.org/article/S0360-3016(16)00163-2/abstract

In reference to your question, for definitive treatment, the article recommends doses between 60-70 Gy. GOG 101 achieved a cCR of 46.5% with 47.6 Gy. GOG 205 had a cCR of 64% with 57.6 Gy. GOG 279 using IMRT is going to 64 Gy I believe.

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