The CROSS trial does not exist in a vacuum. We have a long history of esophageal trials by the RTOG and other cooperative groups that consistently used chemoradiation to 5040 cGy, and this remains the standard of care in the U.S. That said, if I have to treat a very long tumor, resulting in lung m...

I agree with @Harvey J. Mamon's answer and 50.4 Gy is the standard preoperative dose at our center. I also agree with the other comments that this dose, since it is identical to the standard definitive dose for esophageal cancer, allows us to have delivered the recommended dose of RT to patients who...

If normal tissue constraints can be met, I always try to achieve a dose goal of 50.4 Gy. That way, if for some reason, the patient is unable to undergo the planned surgical resection, he will have received a definitive dose of RT. I usually will perform a cone down at 45 Gy to help limit dose to the...

I think its crucial to note the role of biology here. The CROSS trial was overwhelmingly adenocarcinomas, whereas the historical trials have been majority squamous cell carcinoma. As such, i think a simple rule of thumb is to look at the chemo. the med/oncs will usually based choice of chemo on h...