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What if any, is your radiation approach to treating hepatic metastases abutting/invading luminal GI structures?

In the setting of a patient with metastatic CRC (RAS mutated) progressing on first-line therapy, with infiltrative liver metastases abutting the gastric wall with threatened invasion, can you utilize RT to prevent gastric invasion/ obstruction? What would be your preferred dose and fractionation? How do you weigh the risk of fistula/perforation with these regimens if the patient is switching to second-line chemotherapy?
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What is your preferred approach to treating hepatic metastases abutting/invading luminal GI structures?

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3 Answers
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Radiation Oncology · University of Nebraska Medical Center
Answered on

My approach to hepatic metastases abutting luminal GI structures is fundamentally conservative. When liver metastases abut or threaten invasion of the stomach, duodenum, or bowel, I do not treat this as a classic SBRT scenario. The priority shifts from local ablation to durable local control and pre...

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Radiation Oncology · AdventHealth Cancer Institute
Answered on · Updated on

If treating with radiation therapy in this context, I would recommend using a hypofractionated approach (e.g., 45-70 Gy in 15 fractions; most frequently 45 Gy due to the ability to meet constraints), compromising coverage as appropriate to spare normal structures, given the luminal structure sparing...

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Radiation Oncology · NYU Grossman School of Medicine
Answered on

There is a difference between abutting and invading, and I would seek to clarify this, either by MRI or endoscopically. If abutting, I would proceed to second-line therapy for systemic control, and recommend hepatic resection as the adjacent stomach will always be an issue for radiation. (This would...

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