What first line therapeutic regimen do you consider most appropriate for metastatic clear cell renal carcinoma presenting with brain metastasis and vasogenic edema?
Answer from: Medical Oncologist at Academic Institution
Yes, it is safe, but I always treat the CNS metastasis first (e.g. SRS). The risk of bleeding in an untreated CNS metastasis with a VEGF TKI is otherwise unacceptable in my opinion. The edema should be treated with steroids as appropriate and I haven't experienced TKIs worsening CNS edema.