What fractionation do you use for consolidative chest RT in extensive stage SCLC?

3 Gy x 10 is arguably the standard of care.

For patients with good performance status, and who do not have extensive disease outside of the thorax (which is clearly a judgment call), we consider 2.5 Gy x 20 with a 2 week break. This is a well-tolerated schedule with respect to esophagitis. For those ...

45/15 to 50/20 in great PS patients with a CR, otherwise 30/10

I agree with Dr Milano. The best evidence is for 3 x 10, and while I frequently use that dose I also try to make a clinical judgement about the patients performance status, the extent of extrathoracic disease (pre and post chemotherapy), and the potential toxicity of treatment. For a patient with ch...

The ED SCLC TRT is used sequentially in responders with residual chest disease and good performance status. In the CREST trial 30 Gy in 10 is a fine TRT for ED SCLC standard. Also, the RTOG chest plus isolated fewer than 3 distant sites study selected 45Gy in 15fx...a scheme that was tolerable, and ...