What guidance do you give patients on fluvoxamine regarding caffeine intake?
Fluvoxamine is a potent inhibitor of CYP1A2, the main enzyme that metabolizes caffeine. Have you found this interaction relevant in clinical practice? What do you tell your patients?
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What guidance do you give regarding caffeine intake for patients on fluvoxamine?
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Psychiatry · Perelman School of Medicine, University of Pennsylvania
Answered on
Fluvoxamine is a potent CYP1A2 and 2C19 inhibitor. CYP1A2 is the major pathway for caffeine metabolism. In one small clinical trial, the half-life of caffeine increased from 5 hours to 31 hours during 50 mg fluvoxamine treatment (Jeppesen et al., PMID 8807660). Thus, I advise patients taking any dos...
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