What hydroxyurea dose do you target for HbSC disease?

Based on results reported recently, hydroxyurea at an average dose of 20.5 mg/kg/day appeared to reduce substantially the rate of acute painful episodes and other sickle cell disease-related events in both adults and children with HbSC disease (Dei-Adomakoh et al., PMID 39647172). Previous studies also suggested some efficacy (Miller et al., PMID 11464988; Steinberg et al., PMID 9326175; Yates et al., PMID 22949140). The benefits of hydroxyurea in HbSC disease might be a result of reducing cell ...