What, if any, oral or IV antibiotic suppression options would you consider for a patient with a history of recurrent fluoroquinolone- and TMP-SMX-resistant ESBL E. coli bacteremia with relapsed ESBL E. coli lumbar spinal hardware infection who previously underwent lumbar I&D with hardware retention and is not a candidate for further surgery?

This is a challenging case and difficult to answer definitively without additional details, particularly the full antibiogram and patient context. In general, while suppressive antibiotics are sometimes used when infected hardware is retained, and further source control is not possible, this is alwa...

I would base this decision on the full susceptibility profile of the isolate, as well as the specifics of the clinical scenario. The full susceptibility profile is not available to me, but if the isolate is susceptible to any oral beta-lactams, these tend to be associated with the fewest side effect...